Key result
Outpatient systolic dysfunction is linked to lower survival versus the general population.
Why the study?
There is little information regarding the burden and characteristics of systolic dysfunction in Japanese communities despite its importance for CHF prevention.
Observational (n=410)
Yes
p-value: p=<0.0001
Systolic dysfunction in Japanese outpatients is associated with high mortality, increasing prevalence with age, and significant comorbidities, highlighting the need for tailored preventive strategies.
Lower survival in outpatients with systolic dysfunction; leaves open whether age-targeted screening improves outcomes.
BACKGROUND: The prevalence of congestive heart failure (CHF) is increasing with the aging of the community. Management of patients with systolic dysfunction (SD) is important for prevention of CHF, but there is little information regarding the burden of SD on Japanese communities. METHODS AND RESULTS: In order to delineate the epidemiological and clinical characteristics of SD patients, the medical records of patients from Sado Island were collected and summarized in 2003. From the 5 years prior to 2003, data for 497 patients were extracted. The mortality rate was significantly higher compared with the general population; and the total number of survivors had decreased to 410 by 2003. The proportion of SD patients in the general population increased sharply after the age of 65 years in males and 70 years in females, reaching 3.3% and 1.7% for men and women, respectively, in their 80 s. In 49% of the patients, the Charlson comorbidity index was > or = 2, whereas 24% of females led a solitary life. CONCLUSIONS: The total count of outpatients with SD is progressively increasing with age. These patients have multiple comorbidities, making the outcome of SD a poor one. The gender difference in disease characteristics and living conditions should be taken into consideration when establishing preventive strategies for CHF in Japanese communities.
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Okura et al. (2007) conducted an observational in Systolic dysfunction (n=410). Systolic dysfunction (LVEF ≤50%) vs. General population was evaluated on Cumulative survival compared to the general population (p=<0.0001). Outpatients with systolic dysfunction had a significantly lower cumulative survival rate compared to the general population, and their prevalence in the community increased progressively with age.
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