Key result
Unstable angina is linked to ~33% higher PBMC caspase-3 activity versus healthy controls.
Why the study?
Apoptotic cell death may play a critical role in cardiovascular diseases based on atherosclerosis, but the relationship between lymphocyte caspase-3 activity and plaque vulnerability is unclear.
Does lymphocyte caspase-3 activity differ across forms of ischemic heart disease and predict atherosclerotic plaque vulnerability?
Cross-Sectional (n=123)
No
Does lymphocyte caspase-3 activity differ across forms of ischemic heart disease and predict atherosclerotic plaque vulnerability?
Absolute Event Rate: 0.122% vs 0.092%
p-value: p=<0.05
Lymphocyte caspase-3 activity is elevated in patients with unstable angina and may serve as a biomarker for assessing atherosclerotic plaque vulnerability.
May link lymphocyte caspase-3 to plaque vulnerability; leaves open predictive utility pending prospective validation.
Could Lymphocyte Caspase-3 Activity Predict Atherosclerotic Plaque Vulnerability? Apoptotic cell death may play a critical role in a variety of cardiovascular diseases, especially in those developing on the basis of atherosclerosis. The goal of this study was to compare the activity of caspase-3 in different forms of ischemic heart disease and to correlate caspase-3 activity with inflammatory and lipid markers as well as risk factors. This enzyme activity was determined in peripheral blood mononuclear cells (PBMC) of 30 patients with stable angina pectoris (SAP), 27 with unstable angina (USAP), 39 with acute ST-elevation myocardial infarction (STEMI) and 27 healthy volunteers by a colorimetric commercially available ELISA method. In the SAP group caspase-3 activity was 0.093±0.036 μmol/mg protein, in patients with STEMI it was 0.110±0.062 μmol/mg protein, and both values were insignificantly higher in comparison with controls (0.092±0.022 μmol/mg protein). In PBMC of USAP patients caspase-3 activity (0.122±0.062 μmol/mg protein) was significantly higher (p<0.05) compared to the control group. In SAP patients caspase-3 activity showed a significant positive correlation with triglicerydes (p<0.05). Caspase-3 activity may be a valid parameter for assessing the atherosclerotic plaque activity, and a new target for therapeutic intervention.
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Ristić et al. (2010) conducted a cross-sectional in Ischemic heart disease (n=123). Unstable angina pectoris vs. Healthy volunteers was evaluated on Caspase-3 activity in peripheral blood mononuclear cells (mmol/mg protein) (p=<0.05). Caspase-3 activity in peripheral blood mononuclear cells was significantly higher in patients with unstable angina pectoris (0.122 mmol/mg protein) compared to healthy controls (0.092 mmol/mg protein, p<0.05).
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