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November 1, 2020HeliyonOpen Access

Epidemiological study of human rabies cases in Bangladesh through verbal autopsy

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Authors

MRMd Sohel RanaUSUmme Ruman SiddiqiSGSumon Ghosh

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Overview

Epidemiological verbal autopsy study uncovers low post-exposure prophylaxis uptake in fatal human rabies cases, highlighting the critical need for accessible vaccine regimens.

Key Points

  • To investigate the epidemiological characteristics, exposure sources, and healthcare-seeking behaviors associated with fatal human rabies cases using enhanced verbal autopsy.
  • Evaluated hospital records and conducted contact tracing using enhanced verbal autopsies with relatives of physician-confirmed human rabies fatalities (N=256) in Bangladesh.
  • Recorded and evaluated sociodemographic parameters, biting animal species, exposure site, incubation duration, and history of post-exposure prophylaxis.
  • Among 256 fatalities, 71.88% were male, 80.47% resided in rural areas, and 47.27% were children under 15; dogs were the primary vector (81.64%), followed by cats (12.11%), jackals (3.91%), and mongooses (2.34%) (P < 0.05).
  • Limbs were the most frequent site of exposure (67.97%), while bites to the head and face demonstrated the shortest incubation period (P < 0.05).
  • Overall, 86.72% of victims received no post-exposure prophylaxis (PEP) and 66.80% sought care from traditional healers; among those receiving PEP (13.28%, n=34), only 8.82% completed the full vaccination course (P < 0.01) and none received rabies immunoglobulin.

Cite This Study

Rana et al. (2020) studied this question.

synapsesocial.com/papers/6aa9238f6db186eb9162e08bhttps://doi.org/10.1016/j.heliyon.2020.e05521
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Re-evaluating the burden of rabies in Africa and Asia.2005 · 1,275 citations
  2. 2Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006–20182020 · 66 citations
  3. 3Awareness of rabies and response to dog bites in a Bangladesh community2016 · 78 citations