What question did this study set out to answer?

To evaluate the technical complexity, economic breakdown, and operational sensitivities of commercial biosynthetic human insulin production using recombinant Escherichia coli.

December 5, 1995Biotechnology and Bioengineering

Computer‐aided process analysis and economic evaluation for biosynthetic human insulin production—A case study

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Authors

DPDemetri PetridesNew Jersey Institute of Technology ESElpida SapidouIntel (United States)JCJohn CalandranisIntel (United States)

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Implication

Techno-economic modeling reveals key cost drivers and scale-up bottlenecks in biosynthetic human insulin manufacturing, highlighting pathways for cost and environmental impact reduction.

Key Points

To evaluate the technical complexity, economic breakdown, and operational sensitivities of commercial biosynthetic human insulin production using recombinant Escherichia coli.
Simulated the large-scale industrial manufacture of human insulin via a proinsulin Trp-E fusion protein intermediate in Escherichia coli.
Performed process design, economic evaluation, and sensitivity analyses using computer-aided bioprocess simulation software.
Characterized the manufacturing cost breakdown and determined the sensitivity of production expenses to key upstream fermentation and downstream purification parameters.
Identified practical engineering strategies to reduce operating costs and minimize environmental impacts in multi-ton biopharmaceutical production.

Cite This Study

Petrides et al. (1995) studied this question.

synapsesocial.com/papers/6aa9240aaa112b81ac0c037d https://doi.org/10.1002/bit.260480516

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Implication

Techno-economic modeling reveals key cost drivers and scale-up bottlenecks in biosynthetic human insulin manufacturing, highlighting pathways for cost and environmental impact reduction.

Computer‐aided process analysis and economic evaluation for biosynthetic human insulin production—A case study

Discussion

Member takes

Implication

Key Points

Cite This Study

Computer‐aided process analysis and economic evaluation for biosynthetic human insulin production—A case study

Discussion

Member takes

Implication

Key Points

Cite This Study

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