The inhibitory effects of tannins on the activation of inactive hyaluronidase and on the degranulation from rat mesentery mast cells induced by compound 48/80 were investigated. Among the tested tannins, 1, 2, 3, 4, 6-penta-O-galloylglucose, 1, 2, 3, 6-tetra-O-galloylglucose (hydrolyzable tannins) and 3, 3'-di-O-galloylprodelphinidin B-2 (condensed tannins) showed the strongest inhibitory effects in both cases. These results suggest that many tannins may possess anti-inflammatory activity and anti-allergic activity.
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Kakegawa et al. (1985) studied this question.