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A young woman with a clinical diagnosis of systemic lupus erythematosus was treated with corticosteroids and azathioprine. Within nine months, she died of a cerebral reticulum cell sarcoma. Previous reports of lymphoma in patients with systemic rheumatic or “autoimmune disease” and in homograft patients undergoing immunosuppression are discussed. A mechanism of recording cases of malignancy in systemic rheumatic disease occurring both with and without immunosuppression is advocated.
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Eleanor A. Lipsmeyer (1972) studied this question.
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