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January 1, 2000Journal of Clinical MicrobiologyOpen Access

Differences in Surface-Exposed Antigen Expression between Helicobacter pylori Strains Isolated from Duodenal Ulcer Patients and from Asymptomatic Subjects

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Authors

ATAnn-Catrin Elisabeth ThoresonUniversity of Gothenburg AHA. HamletMcMaster University Medical Centre JÇJanet ÇelikKarolinska Institutet

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Implication

Observational analysis reveals enriched Lewis y and BabA expression in duodenal Helicobacter pylori strains from ulcer patients, indicating a link to tissue inflammation.

Key Points

To identify qualitative and quantitative differences in surface-exposed antigen expression between Helicobacter pylori strains isolated from duodenal ulcer patients and asymptomatic individuals.
Analyzed H. pylori strains isolated from the antrum and duodenum of 21 duodenal ulcer (DU) patients and 20 asymptomatic subjects (AS).
Characterized bacterial surface antigen profiles using enzyme-linked immunosorbent assay (ELISA) and inhibition ELISA.
Duodenal strains from DU patients expressed the Lewis y (Le(y)) antigen significantly more often than strains from AS (P < 0.05), with Le(y) presence correlating with active duodenitis severity (P < 0.05).
Strains from AS were significantly more likely to be Lewis nontypeable compared to those from DU patients (P < 0.01).
Expression of the blood group antigen-binding adhesin (BabA) was significantly higher in both antral and duodenal strains from DU patients compared to AS (P < 0.05), and BabA-positive duodenal strains correlated with active duodenitis (P < 0.01).

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Thoreson et al. (2000) studied this question.

synapsesocial.com/papers/6aa928fa9965218ad462e00b https://doi.org/10.1128/jcm.38.9.3436-3441.2000

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Implication

Observational analysis reveals enriched Lewis y and BabA expression in duodenal Helicobacter pylori strains from ulcer patients, indicating a link to tissue inflammation.

Differences in Surface-Exposed Antigen Expression between Helicobacter pylori Strains Isolated from Duodenal Ulcer Patients and from Asymptomatic Subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

Differences in Surface-Exposed Antigen Expression between Helicobacter pylori Strains Isolated from Duodenal Ulcer Patients and from Asymptomatic Subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

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