Key result
Norovirus infects ~5% of young Bangladeshi children with acute gastroenteritis, predominantly the GII.7 genotype.
Why the study?
Acute gastroenteritis is a major cause of pediatric morbidity and mortality worldwide, prompting investigation into the genotype diversity and molecular epidemiology of norovirus in Bangladesh.
Cross-Sectional (n=466)
Norovirus is a significant etiology of acute gastroenteritis in children under 5 in Bangladesh, with GII.7 being the predominant genotype.
Answers are grounded in this paper and cite their sources.
Should not yet change clinical management of pediatric gastroenteritis; leaves open the need for longitudinal surveillance to guide prevention in Bangladesh.
Acute gastroenteritis (AGE) is one of the most common diseases in children, and it continues to be a significant cause of morbidity and mortality worldwide. Norovirus is one of the major enteropathogens associated with both sporadic diarrhea and outbreaks of gastroenteritis. This study aims to investigate genotype diversity and molecular epidemiology of norovirus in Bangladesh. A total of 466 fecal specimens were collected from January 2014 to January 2019 from children below 5 years old with AGE in Bangladesh. All samples were analyzed by reverse transcriptase polymerase chain reaction to detect norovirus, and sequence analysis was conducted if found positive. Norovirus was detected in 5.1% (24 of 466) fecal specimens. Norovirus genotype GII.7 was predominant (62.5%, 15 of 24), followed by GII.3 (37.5%, 9 of 24). Coinfection between rotavirus and norovirus was found in 7 of 24 positive cases. Diarrhea (93.7%) and dehydration (89%) were the most common symptoms in children with AGE. About 80% of the positive cases were detected in children aged under 24 months. One seasonal peak (87.5% infection) was detected in the winter. This study suggests that norovirus continues to be one of the major etiologies of children AGE in Bangladesh. This study will provide a guideline to assess the burden of norovirus infection in Bangladesh, which will assist to combat against AGE.
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Dey et al. (2021) conducted a cross-sectional in Acute gastroenteritis (n=466). Norovirus infection was evaluated on Norovirus detection. Norovirus infection was detected in 5.1% of children under 5 with acute gastroenteritis in Bangladesh, with genotype GII.7 being the predominant strain.
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