Key result
Ultrasound-stimulated microbubbles penetrate fibrin clots to form patent fluid tunnels and deform clot boundaries.
Why the study?
The mechanisms by which ultrasound stimulated microbubbles potentiate blood clot lysis are not well understood, particularly their interaction with fibrin clots.
Answers are grounded in this paper and cite their sources.
Demonstrates the physical mechanisms by which ultrasound-stimulated microbubbles enhance clot lysis, including clot penetration and fluid transport.
While it is well established that ultrasound stimulated microbubbles (USMBs) can potentiate blood clot lysis, the mechanisms are not well understood. Here we examine the interaction between USMBs and fibrin clots, which are comprised of fibrin networks that maintain the mechanical integrity of blood clots. High speed camera observations demonstrated that USMBs can penetrate fibrin clots. Two-photon microscopy revealed that penetrating bubbles can leave behind patent “tunnels” along their paths and that fluid can be transported into the clots. Finally, it is observed that primary radiation forces associated with USMBs can induce local deformation and macroscopic translation of clot boundaries.
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Acconcia et al. (2013) studied Fibrin clots. Ultrasound stimulated microbubbles (USMBs) was evaluated on Interaction between USMBs and fibrin clots. Ultrasound stimulated microbubbles can penetrate fibrin clots, leaving patent tunnels for fluid transport, and induce local deformation and macroscopic translation of clot boundaries.
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