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August 6, 2008Proceedings of the National Academy of SciencesOpen Access

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

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Authors

AWAdam B. WeinglassMerck & Co., Inc., Rahway, NJ, USA (United States)MKMartin KöhlerKarolinska InstitutetUSUwe SchulteUniversity of Freiburg

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Weinglass et al. (2008) studied this question.

synapsesocial.com/papers/6aa92d391189ba99418787f1https://doi.org/10.1073/pnas.0800936105
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia2003 · 401 citations
  2. 2Topological Analysis of Niemann-Pick C1 Protein Reveals That the Membrane Orientation of the Putative Sterol-sensing Domain Is Identical to Those of 3-Hydroxy-3-methylglutaryl-CoA Reductase and Sterol Regulatory Element Binding Protein Cleavage-activating Protein2000 · 303 citations
  3. 3Effect of Ezetimibe Coadministered With Atorvastatin in 628 Patients With Primary Hypercholesterolemia2003 · 687 citations
  4. 4The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)2005 · 773 citations