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January 1, 2010Open Access

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

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Authors

MYMichael B. YaffeBroad InstituteTBThijn R. BrummelkampCentrum Wiskunde & InformaticaHRHans Christian ReinhardtGerman Cancer Research Center

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Yaffe et al. (2010) studied this question.

synapsesocial.com/papers/6aa92db433d92521facdbf83https://doi.org/10.1371/journal.pbio.1000287
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.1994 · 255 citations
  2. 2Linear Motif Atlas for Phosphorylation-Dependent Signaling2008 · 465 citations
  3. 3Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks2006 · 529 citations
  4. 4NFBD1, Like 53BP1, Is an Early and Redundant Transducer Mediating Chk2 Phosphorylation in Response to DNA Damage2003 · 101 citations
  5. 5Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk11997 · 250 citations