What question did this study set out to answer?

To review the working principles, analytical performance, limitations, and pharmaceutical applications of pure shift yielded by chirp excitation (PSYCHE) NMR spectroscopy.

August 21, 2026Journal of Pharmaceutical and Biomedical Analysis OpenOpen Access

A comprehensive review on applications of pure shift yielded by chirp excitation nuclear magnetic resonance (PSYCHE NMR) in pharmaceutical analysis

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Authors

MVMeet VegdaNirma University VVVivek K. VyasNational Forensic Sciences University

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Implication

Review highlights pure shift yielded by chirp excitation NMR techniques in pharmaceutical analysis, indicating its utility as a complementary tool to improve spectral resolution.

Key Points

To review the working principles, analytical performance, limitations, and pharmaceutical applications of pure shift yielded by chirp excitation (PSYCHE) NMR spectroscopy.
Examined the broadband homonuclear decoupling mechanism of PSYCHE, which integrates low-flip-angle frequency-swept chirp pulses with weak pulsed field gradients.
Surveyed practical implementations across diverse pharmaceutical compounds—such as azithromycin, dexamethasone, and ibuprofen—alongside computational spin-analysis software.
PSYCHE suppresses proton-proton scalar couplings during signal generation, simplifying first-order multiplets into pseudo-singlets while maintaining chemical shift positions.
Primary analytical constraints include compromised signal sensitivity, broadened line widths, and imperfect multiplet compression in strongly coupled spin systems.
Combining PSYCHE with advanced quantum-mechanical modeling software substantially enhances spectral dispersion and structural elucidation compared to conventional proton NMR alone.

Cite This Study

Vegda et al. (2026) studied this question.

synapsesocial.com/papers/6aa92ed511a60bccbd263d4f https://doi.org/10.1016/j.jpbao.2026.100117

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Implication

Review highlights pure shift yielded by chirp excitation NMR techniques in pharmaceutical analysis, indicating its utility as a complementary tool to improve spectral resolution.

A comprehensive review on applications of pure shift yielded by chirp excitation nuclear magnetic resonance (PSYCHE NMR) in pharmaceutical analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

A comprehensive review on applications of pure shift yielded by chirp excitation nuclear magnetic resonance (PSYCHE NMR) in pharmaceutical analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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