Key result
Plasma extracellular vesicles from obese patients induce renal tubule injury and RAS activation via miR-6869-5p.
Why the study?
Extracellular vesicles transmit information in obesity and cause remote organ damage, but whether plasma EV cargo miR-6869-5p causes local renal tubular RAS activation and damage was unclear.
Does miR-6869-5p transported by plasma extracellular vesicles mediate renal tubule injury and RAS activation in obesity?
Does miR-6869-5p transported by plasma extracellular vesicles mediate renal tubule injury and RAS activation in obesity?
p-value: p=<0.001
Plasma Obese-EVs induce renal tubule injury and RAS activation via miR-6869-5p transport, suggesting a potential therapeutic target for obesity-associated kidney disease.
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Hypothesis-generating for miR-6869-5p in obesity kidney disease; leaves open human translation and clinical relevance.
Liu et al. (2021) studied Obesity-associated kidney disease (n=50). Plasma extracellular vesicles from obese patients (Obese-EVs) vs. Plasma extracellular vesicles from lean subjects (Lean-EVs) was evaluated on Renal tubule injury and renin-angiotensin system (RAS) activation markers (p=<0.001). Plasma extracellular vesicles from obese patients induced renal tubule injury and renin-angiotensin system activation in proximal tubular epithelial cells via transport of miR-6869-5p.
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