May 1, 1994Current Opinion in Nephrology & Hypertension
The use of antihypertensive agents in prevention and treatment of diabetic nephropathy
Key result
ACE inhibitors and conventional antihypertensives delay end-stage renal failure and improve survival in IDDM nephropathy.
Why the study?
Do antihypertensive agents (ACE inhibitors, beta-blockers, diuretics) prevent or delay the progression of diabetic nephropathy in patients with diabetes mellitus?
Population
Patients with insulin-dependent diabetes mellitus and non-insulin-dependent diabetes mellitus with…
Comparison
Antihypertensive agents vs Conventional antihypertensive treatment or no…
Design
Review
Authors
Discussion
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Member takes
Implication
Supports ACE inhibitor use in type 1 diabetic nephropathy; leaves open optimal regimens and efficacy in type 2 diabetes.
Structured PICO
Do antihypertensive agents (ACE inhibitors, beta-blockers, diuretics) prevent or delay the progression of diabetic nephropathy in patients with diabetes mellitus?
P
Population
Patients with insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) with microalbuminuria or overt diabetic nephropathy
I
Intervention
Antihypertensive agents (specifically ACE inhibitors, beta-blockers, and diuretics)
C
Comparator
Conventional antihypertensive treatment or no treatment/placebo
O
Outcome
Progression of diabetic nephropathy (including urinary albumin excretion rate, loss of kidney function, time to doubling of serum creatinine, end-stage renal failure, and survival)
ACE inhibitors and conventional antihypertensive therapies are effective in slowing the progression of diabetic nephropathy and improving survival in patients with type 1 diabetes, though data in type 2 diabetes remains limited.
Limitations
- No information is available on postponing end-stage renal failure and improving survival in NIDDM patients with diabetic nephropathy.
- Lack of information on end-stage renal failure and survival outcomes in NIDDM patients with diabetic nephropathy
Cite This Study
Parving et al. (1994) conducted a review in Diabetic nephropathy. Antihypertensive agents was evaluated. ACE inhibitors and conventional antihypertensive treatments postpone end-stage renal failure and improve survival in IDDM patients with diabetic nephropathy.