Key result
INIA19 template reveals higher ALFF activity in the left hippocampus versus right in macaques.
Why the study?
The study aimed to develop a method for delineating regions of interest and extracting ALFF values from specific brain regions using the macaque brain atlas to enhance analysis specificity and accuracy.
A novel method for extracting ALFF values in specific macaque brain regions reveals significant lateralization in hippocampal activity.
Hippocampal lateralization in macaques is hypothesis-generating; leaves open relevance to human neuroimaging or disease models.
Objective: This study aimed to develop a method for delineating regions of interest and extracting amplitude of low-frequency fluctuation (ALFF) values from specific brain regions using the macaque brain atlas to enhance analysis specificity and accuracy. Methods: The INIA19 template was utilized to create a hippocampal mask, following which the ALFF in the hippocampus was derived from resting-state functional magnetic resonance imaging (fMRI) data obtained from three macaques. Results:Bilateral hippocampal and region-specific masks were successfully generated. Analysis of low-frequency amplitude values revealed significant differences in activity levels between the left and right hippocampi, CA1, CA2 regions. Specifically, the left hippocampus, CA1, and CA2 regions exhibited higher amplitude activity compared to their right-sided counterparts. Conversely, no significant differences were observed between the left CA3 and right DG regions and their contralateral counterparts. Conclusions: Implementing the production and extraction of ALFF values in specific brain regions facilitates a deeper understanding of brain activity complexities and offers novel insights into brain functional networks in cognitive neuroscience.
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Jing Li (2024) studied this question. ALFF extraction using INIA19 template was evaluated on Differences in ALFF values between left and right hippocampal regions. Extracting amplitude of low-frequency fluctuation values using the INIA19 template revealed higher activity in the left hippocampus, CA1, and CA2 regions compared to the right in 3 macaques.
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