Key result
Serologic profiling demonstrates ~60% rotavirus immunity among Brazilian children under five.
Cross-Sectional (n=399)
No
The study demonstrates early acquisition of rotavirus antibodies in Brazilian children, though 36% remain nonimmune and susceptible to severe infection.
Substantial rotavirus susceptibility persists in Brazilian children under 5; leaves open optimal vaccination strategies pending prospective data.
The age distribution of antibody to simian rotavirus (SA-11) was studied in serum specimens obtained from 399 children aged to 5 years and living in the city of Recife (PE), located in the north eastern region of Brazil. Sera were examined for group-specific rotavirus antibody using a blocking enzyme immunoassay (bELISA) and a hemagglutination inhibition antibody (HIA) test, and for anti-VP2, anti-VP4, anti-VP6, and anti-VP7 antibodies using an immunoblotting assay (IBA). Antibody prevalence was similar in all bELISA and HIA assays, showing a steep rise in the 6-to 17-month-old age groups. The results indicate early acquisition of antibody to rotavirus. The majority of children aged 2 to 4 years had bELISA (50% to 60%) and HIA (70% to 81%) antibodies. There was an association in prevalence data obtained by HIA and bELISA with immunoblotting (IBA), revealing four serologic profiles. Children with profiles I and II (60%) respectively had HAI and ELISA antibody or HAI antibody alone and all had immunoprotective antibodies to VP4 and/or VP7. These children were regarded as "immune," resembling convalescent patients with a rotavirus infection. Children with profile III (4%) had no HIA antibody and only non-protective anti-VP6 and/or VP7 antibody, and were considered to be "partially immune." Children with profile IV (36%) had no detectable antibody and were classified as "nonimmune." These children should be considered to be susceptible to rotavirus infection, with the risk of developing clinically severe diarrhea.
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Andrade et al. (1996) conducted a cross-sectional in Rotavirus immunity (n=399). Rotavirus exposure was evaluated on Prevalence of rotavirus antibodies and serologic profiles. Serologic profiling of 399 Brazilian children under 5 years of age revealed that 60% were immune to rotavirus, 4% were partially immune, and 36% were nonimmune and susceptible to infection.
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