Key result
Group C rotavirus antibody prevalence was low in children under 5 years and increased to 36% in adults, reflecting continuous exposure to primary infection across all age groups.
Cross-Sectional
Group C rotavirus seroprevalence increases with age to 36% in adults in a Brazilian suburban community, suggesting continuous exposure and independent transmission from group A rotavirus.
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Group C rotavirus seroprevalence data suggest ongoing adult exposure; hypothesis-generating for its independent role in gastroenteritis and need for prospective studies.
Group C rotaviruses are associated with sporadic outbreaks of gastroenteritis worldwide. Age-specific seroprevalence of group C rotavirus antibodies was investigated in sera, randomly collected and representative of a suburban community in Brazil which had previously been screened for group A rotavirus antibodies. Antibody prevalence to group C rotavirus was low in children under 5 years and increased slowly with age to 36% seropositivity in adults, reflecting continuous exposure to primary infection in all age groups. This suggests a higher incidence of infection than disease might predict. Adult antibody prevalence was similar to that in other geographical settings. No obvious patterns of infection with group A and group C rotavirus were found within individuals, which suggests independent transmission. However, further epidemiological studies are required to understand group C rotavirus dynamics and possible interactions with group A rotavirus transmission and immunity.
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Cox et al. (1998) conducted a cross-sectional in Group C rotavirus infection. Group C rotavirus exposure was evaluated on Age-specific seroprevalence of group C rotavirus antibodies. Group C rotavirus antibody prevalence was low in children under 5 years and increased to 36% in adults, reflecting continuous exposure to primary infection across all age groups.
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