Key result
Following the 2006 introduction of the rotavirus vaccine in Brazil, studies report a decrease in overall rotavirus detection and a high prevalence of the G2P[4] genotype.
Why the study?
Does the rotavirus vaccination program alter the circulating rotavirus genotypes and detection rates in children under five years in Brazil?
Population
Children under the age of five years in Brazil
Comparison
Rotavirus vaccination program established in 2006 vs Pre-vaccination era
Design
Review
Authors
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Continued surveillance of rotavirus genotypes is warranted post-vaccination; leaves open whether G2P[4] predominance reflects vaccine pressure.
Does the rotavirus vaccination program alter the circulating rotavirus genotypes and detection rates in children under five years in Brazil?
The introduction of the rotavirus vaccine in Brazil was followed by a decrease in rotavirus detection and a high prevalence of the G2P[4] genotype, though it remains unclear if this is due to vaccine selective pressure.
Thabata Alessandra Ramos Caruzo (2011) conducted a review in Severe acute gastroenteritis caused by rotavirus. Nationwide rotavirus vaccination program vs. Pre-vaccination era was evaluated on Rotavirus genotypes circulating and rotavirus detection rates. Following the 2006 introduction of the rotavirus vaccine in Brazil, studies report a decrease in overall rotavirus detection and a high prevalence of the G2P[4] genotype.
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