Key result
Introduction of the monovalent rotavirus vaccine was associated with a reduction in rotavirus detection among severe diarrhea cases from 27% to 5.0% in Recife, Brazil.
Why the study?
Does the introduction of a monovalent rotavirus vaccine alter the circulating rotavirus genotypes and reduce severe diarrhea cases in Brazil?
Population
Patients with severe diarrhea in northeastern Brazil (Aracaju and Recife)
Comparison
Human monovalent rotavirus vaccine (G1P[8]) vs Pre-vaccine period
Design
Editorial
Authors
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The introduction of the monovalent rotavirus vaccine in Brazil significantly reduced severe rotavirus diarrhea but was associated with a relative increase in the P[4]G2 genotype.
Does the introduction of a monovalent rotavirus vaccine alter the circulating rotavirus genotypes and reduce severe diarrhea cases in Brazil?
Absolute Event Rate: 5% vs 27%
The introduction of the monovalent rotavirus vaccine in Brazil significantly reduced severe rotavirus diarrhea but was associated with a relative increase in the P[4]G2 genotype.
Linhares et al. (2008) conducted a letter in Rotavirus infection. Monovalent rotavirus vaccine (G1P[8]) vs. Pre-vaccine period was evaluated on Detection rate of rotavirus among severe diarrhea cases. Introduction of the monovalent rotavirus vaccine was associated with a reduction in rotavirus detection among severe diarrhea cases from 27% to 5.0% in Recife, Brazil.
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