Key result
The human rotavirus vaccine reduced the risk of severe rotavirus diarrhea among children under 1 year of age (7% vs 26% in nonvaccinated; OR 0.20) despite the predominance of the P[4]G2 strain.
Population
Children with severe diarrhea in northeastern Brazil (Aracaju and Recife)
Comparison
Human, monovalent rotavirus vaccine (G1P[8]) vs Pre-vaccine period
Design
Editorial
Authors
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The introduction of the monovalent rotavirus vaccine in Brazil significantly reduced severe rotavirus diarrhea but was associated with a relative increase in the P[4]G2 genotype.
Odds Ratio: 0.2 (95% CI 0.029–1.24)
Absolute Event Rate: 7% vs 26%
p-value: p=<0.05
The introduction of the monovalent rotavirus vaccine in Brazil significantly reduced severe rotavirus diarrhea but was associated with a relative increase in the P[4]G2 genotype.
Patel et al. (2008) conducted a letter in Severe rotavirus diarrhea. Human rotavirus vaccine vs. Nonvaccinated was evaluated on Severe rotavirus diarrhea (OR 0.20, 95% CI 0.029-1.24, p=<0.05). The human rotavirus vaccine reduced the risk of severe rotavirus diarrhea among children under 1 year of age (7% vs 26% in nonvaccinated; OR 0.20) despite the predominance of the P[4]G2 strain.
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