Key result
Following the introduction of the rotavirus vaccine, the rotavirus detection rate among hospitalized children with gastroenteritis significantly decreased from 38% in 2005 to 24% in 2007.
Why the study?
Does the introduction of the G1P[8] rotavirus vaccine alter the rotavirus detection rate and genotype distribution in hospitalized children with gastroenteritis?
Population
464 hospitalized children from birth to 5 years of age with gastroenteritis and dehydration requiring…
Comparison
Introduction of monovalent G1P[8] rotavirus… vs Pre-vaccination period (2005).
Design
Cross-sectional
Authors
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Supports rotavirus vaccination in reducing pediatric hospitalizations; leaves open long-term effects of genotype shifts on efficacy.
Observational (n=464)
No
Does the introduction of the G1P[8] rotavirus vaccine alter the rotavirus detection rate and genotype distribution in hospitalized children with gastroenteritis?
Absolute Event Rate: 24% vs 38%
p-value: p=0.012
The introduction of the rotavirus vaccine in Brazil was associated with a decreased overall rotavirus detection rate but a significant shift in genotype distribution toward G2P[4].
Carvalho‐Costa et al. (2008) conducted an observational in Gastroenteritis and dehydration (n=464). Rotavirus vaccine introduction vs. Prevaccination period was evaluated on Rotavirus detection rate (p=0.012). Following the introduction of the rotavirus vaccine, the rotavirus detection rate among hospitalized children with gastroenteritis significantly decreased from 38% in 2005 to 24% in 2007.
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