[Inhibitory effect of ketogenic diet on neuroblastoma in BALB/c-nu mouse models].

This is the authors' abstract. We don't add key points for this paper.

OBJECTIVE: To investigate the inhibitory effect of ketogenic diet (KD) on growth of neuroblastoma in mice. METHODS: =8. The tumor volume, body weight, blood glucose, ketone body (β-Hydroxybutyrate) levels, and hepatic steatosis in the mice were assessed. The expressions of caspase-3 and caspase-8 were detected by Western blotting, and Ki67 expresison was detected using immunohistochemistry (IHC). Transmission electron microscopy (TEM) was employed for the autophagosomes, and the autophagic protein Beclin1, LC3A/B and P62 were detected by IHC and Western blotting. CONCLUSIONS: KD has a strong anti-tumor effect in the xenograft mouse model possibly by regulating cell autophagy.