Key result
Nonfunctioning adrenal incidentaloma linked to ~25% longer inter-atrial electromechanical delay and increased LVMI.
Why the study?
Data regarding morphological and functional cardiac alterations are limited in patients with nonfunctioning adrenal incidentaloma, necessitating investigation of associated cardiac morbidity.
Do patients with nonfunctioning adrenal incidentaloma have subclinical cardiac alterations and prolonged atrial electromechanical delay compared to matched controls?
Cross-Sectional (n=76)
Single-blind
No
Do patients with nonfunctioning adrenal incidentaloma have subclinical cardiac alterations and prolonged atrial electromechanical delay compared to matched controls?
Absolute Event Rate: 23.53% vs 18.85%
p-value: p=0.008
Patients with nonfunctioning adrenal incidentalomas exhibit subclinical cardiac alterations, including increased LV mass index and prolonged atrial electromechanical delays, suggesting a potential need for cardiovascular risk monitoring.
Supports subclinical cardiac involvement in nonfunctioning adrenal incidentaloma; leaves open need for prospective validation before monitoring changes.
BACKGROUND: Majority of the incidentally discovered adrenal masses, called adrenal incidentaloma (AI), are nonfunctioning adrenal adenomas. The appropriate management of AI is still a matter debate, so it is necessary to investigate their associated morbidity. However, data regarding morphological and functional cardiac alterations are limited in this group. OBJECTIVE: In this study, we aimed to assess cardiac structural and functional characteristics and atrial conduction properties in patients with nonfunctioning AI. METHODS: Thirty patients with nonfunctioning AI and 46 properly matched control subjects were included in the study. After hormonal and biochemical analysis, all participants underwent transthoracic echocardiography to obtain systolic and diastolic parameters of both ventricles, in addition to atrial conduction times by tissue Doppler echocardiography. Data were analyzed with Statistical Package for the Social Sciences (SPSS, Chicago, IL, United States) statistics, version 17.0 for Windows. P < 0.05 was considered statistically significant. RESULTS: Left ventricular (LV) mass index and LV myocardial performance index were significantly increased in AI group. Among atrial conduction times, both intra- and interatrial electromechanical delays were significantly prolonged in patients with nonfunctioning AI. Other laboratory and echocardiographic findings were similar between groups. CONCLUSION: Our study revealed that intra- and inter-atrial conduction times were prolonged, and LV mass index was increased in patients with nonfunctioning AI. These findings may be markers of subclinical cardiac involvement and tendency to cardiovascular complications. Close follow-up is necessary for individuals with nonfunctioning AI for their increased cardiovascular risk.
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Sökmen et al. (2018) conducted a cross-sectional in Nonfunctioning Adrenal Incidentaloma (n=76). Nonfunctioning Adrenal Incidentaloma vs. Matched controls without adrenal mass was evaluated on Inter-atrial electromechanical delay (ms) (p=0.008). Nonfunctioning adrenal incidentaloma was associated with significantly prolonged inter-atrial electromechanical delay (23.53 vs 18.85 ms) and increased left ventricular mass index compared to controls.
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