Synthesis of CH2-Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation

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C -Linked carbohydrate structure, in which the cleavable O -glycosidic linkage is replaced by a carbon unit, is a useful tool for functional analyses of glycoconjugates. We describe a synthetic method for α-CH 2 -linked disaccharide structures, such as Glc(1,6)-Glc, by stereoselective radical-coupling C -glycosylation between a conformationally constrained and stable C1-sp 3 hybridized xanthate donor and a carefully designed acceptor.