Key result
Implementation of personalized preventive approaches faces ~280 barriers across six major domains.
Why the study?
The implementation of personalized preventive approaches for chronic diseases in real-world health systems is constrained by several barriers that need mapping.
Systematic Review (n=37)
Implementation of personalized preventive approaches in real-world settings is constrained by 283 barriers across six main domains, highlighting the need for targeted strategies to overcome these hurdles.
Substantial barriers impede personalized prevention uptake; extends implementation research by mapping six domains for targeted strategies.
INTRODUCTION: The growing prevalence of chronic diseases globally raised the public health need to improve the effectiveness of preventive medicine through the integration of big data, biological biomarkers and omics technologies. The implementation of personalized preventive approaches in real-world settings is constrained by several barriers. This scoping review aimed to map the barriers hindering the adoption of personalized preventive approaches for chronic diseases in health systems. MATERIALS AND METHODS: PubMed, Web of Science, Scopus and gray literature sources were consulted from 2017 to 2024, to collect reviews on personalized preventive approaches implementation's barriers. Additionally, we conducted a thematic analysis in order to categorize the identified barriers. The review followed Arksey-O'Malley guidelines and PRISMA-ScR checklist. RESULTS: 283 barriers were extracted from 37 reviews, and categorized into six main domains, namely "Research" (30 reviews), "Organizational Aspects" (27 reviews), "Healthcare Professionals" (28 reviews), "Ethical, Legal, and Social Issues" (29 reviews), "Public" (24 reviews), and "Financial concerns" (23 reviews). The research domain was characterized by lack of generalizability, clinical efficacy and cost effectiveness evidence. Organizational barriers included operational inefficiencies and unclear implementation frameworks. Healthcare professionals struggle with insufficient personalized prevention literacy. Ethical concerns, data privacy issues, and health inequities represent a burden to deal with for actual translation into practice, as well as the general mistrust of individuals and inadequate financial mechanisms. CONCLUSIONS: Our findings showed how several factors threaten the progress of many innovations in the field of personalized prevention across different populations and chronic diseases, highlighting the need for further efforts in personalized preventive approaches implementation.
No takes yet. Share an insight, caveat, or question.
Scarsi et al. (2025) conducted a systematic review in Chronic diseases (n=37). Personalized preventive approaches was evaluated on Barriers to the implementation of personalized preventive approaches. A scoping review of 37 reviews identified 283 barriers to implementing personalized preventive approaches, categorized into research, organizational, professional, ethical, public, and financial domains.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: