Key result
Positive postoperative CEA predicts ~215% higher progression risk in stage II and III colorectal cancer.
Why the study?
Few studies have demonstrated the impacts of postoperative CEA and post-preoperative CEA increment on the prognosis of colorectal cancer.
Does positive postoperative serum CEA and post-preoperative CEA increment predict worse progression-free and overall survival in patients with stage II and III colorectal cancer?
Population
1008 stage II and III CRC patients who underwent radical surgery
Comparison
Four groups based on postoperative serum CEA levels and post-preoperative CEA trends
Design
Multicenter retrospective study
Authors
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May aid postoperative risk stratification in stage II/III colorectal cancer; hypothesis-generating pending prospective validation.
Cohort (n=1,008)
Yes
Does positive postoperative serum CEA and post-preoperative CEA increment predict worse progression-free and overall survival in patients with stage II and III colorectal cancer?
Hazard Ratio: 3.149 (95% CI 2.426–4.088)
Absolute Event Rate: 29% vs 75.8%
p-value: p=0.000
Positive postoperative CEA and post-preoperative CEA increment are strong independent predictors of worse progression-free and overall survival in stage II and III colorectal cancer.
You et al. (2020) conducted a cohort in Stage II and III Colorectal Cancer (n=1,008). Positive postoperative CEA (>5 ng/ml) vs. Negative postoperative CEA (≤5 ng/ml) was evaluated on Progression-free survival (PFS) (HR 3.149, 95% CI 2.426-4.088, p=0.000). Positive postoperative CEA independently predicted worse progression-free survival (HR 3.149) and overall survival (HR 3.414) in patients with stage II and III colorectal cancer.
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