Key result
The TMEM16A channel serves as a versatile transducer of vasoactive stimuli in both arterial smooth muscle and endothelial cells to enable fine modulation of vessel tone.
Highlights a previously unidentified role for the TMEM16A channel in endothelial cells for acetylcholine-mediated vasorelaxation.
The TMEM16A channel represents a key depolarizing mechanism in arterial smooth muscle and contractile pericytes, where it is activated by several endogenous contractile agonists. In this issue of Science Signaling , Mata-Daboin et al. demonstrate a previously unidentified role for TMEM16A in endothelial cells for acetylcholine-mediated vasorelaxation. Collectively, TMEM16A serves as a transducer of vasoactive stimuli to enable fine modulation of vessel tone.
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Paolo Tammaro (2023) conducted an editorial in Vascular tone regulation. TMEM16A channel was evaluated. The TMEM16A channel serves as a versatile transducer of vasoactive stimuli in both arterial smooth muscle and endothelial cells to enable fine modulation of vessel tone.
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