Sodium-ion-responsive injectable supramolecular hydrogel delivers engineered Salmonella for safer and enhanced tumor immunotherapy

Q: What does this research mean for the field?

A sodium-ion-responsive injectable supramolecular hydrogel (1,6-DAS) delivering engineered Salmonella enhances tumor immunotherapy by effectively balancing therapeutic efficacy and safety. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Wenliang Yu; Wei Tang; Tao Zhang; Mengyue Gao; Lina Liu; Xiaoran Zhou; Zeyang Liu; Ziyi Tan; Yao Li; Yuning Meng; Siyu Li; Chenyang Li; Congrui Guo; Kaiting Zheng; Zichun Hua

doi:10.1016/j.xinn.2026.101363

March 31, 2026The InnovationOpen Access

Sodium-ion-responsive injectable supramolecular hydrogel delivers engineered Salmonella for safer and enhanced tumor immunotherapy

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Abstract

T cells in the tumor microenvironment. Overall, the 1,6-DAS hydrogel provides a promising approach to address the core challenge of balancing efficacy and safety in VNP-based therapies, with substantial potential to propel microbiome-driven cancer immunotherapy forward.

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Yu et al. (2026) studied this question.

synapsesocial.com/papers/6aa9344f04014c9901263ef2 https://doi.org/10.1016/j.xinn.2026.101363

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Sodium-ion-responsive injectable supramolecular hydrogel delivers engineered Salmonella for safer and enhanced tumor immunotherapy

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Abstract

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Sodium-ion-responsive injectable supramolecular hydrogel delivers engineered Salmonella for safer and enhanced tumor immunotherapy

Ask about this paper

Abstract

Discussion

Cite This Study

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