Key result
Excessive alcohol consumption in men is linked to ~258% higher vitamin B12 levels versus moderate drinking.
Why the study?
Alcohol dependence is rapidly increasing globally and in developing countries, but the serum levels of vitamin B12 and vitamin D in chronic alcoholic patients and their link to liver function parameters required analysis.
Does excessive alcohol consumption affect serum vitamin B12 and vitamin D levels compared to moderate consumption in male patients with alcohol dependence?
Population
Male patients visiting a psychiatric OPD for alcohol dependence treatment in Nepal
Comparison
Excessive drinkers vs moderate drinkers
Design
Cross-sectional study
Authors
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Caution interpreting B12 elevations as repletion in heavy drinkers; leaves open mechanisms and vitamin D implications in alcohol dependence.
Cross-Sectional (n=80)
No
Does excessive alcohol consumption affect serum vitamin B12 and vitamin D levels compared to moderate consumption in male patients with alcohol dependence?
Absolute Event Rate: 925.9% vs 258.4%
p-value: p=<0.001
In male patients with alcohol dependence, excessive drinking is associated with higher vitamin B12 levels (correlated with liver function parameters) and high rates of vitamin D insufficiency.
Jayan et al. (2021) conducted a cross-sectional in Alcohol dependence (n=80). Excessive alcohol consumption vs. Moderate alcohol consumption was evaluated on Median serum vitamin B12 levels (pg/ml) (p=<0.001). Excessive alcohol consumption in male patients was associated with significantly higher median serum vitamin B12 levels (925.9 pg/ml) compared to moderate drinking (258.4 pg/ml, p<0.001).
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