Why the study?
The relationship between cold exposure-induced metabolic changes in glucose, lipid, and amino acid metabolism and UCP1-mediated thermogenesis in brown adipose tissue was not fully understood.
Population
Wild-type and UCP1-KO mice
Comparison
Wild-type vs UCP1-KO mice after 4-h exposure to cold temperature (10 °C)
Design
Preclinical metabolomic and GeneChip array comparative study
Key result
Acute cold exposure induced UCP1-mediated thermogenesis-dependent glucose utilization and UCP1-independent active lipid metabolism in the brown adipose tissue of mice.
Authors
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No immediate clinical implications; leaves open translation of murine BAT pathways to human metabolic therapies.
Acute cold exposure induces both UCP1-dependent glucose utilization and UCP1-independent lipid metabolism in the brown adipose tissue of mice.
Okamatsu‐Ogura et al. (2020) studied this question. Acute cold exposure vs. UCP1-KO mice was evaluated on Metabolomic and gene expression changes in brown adipose tissue. Acute cold exposure induced UCP1-mediated thermogenesis-dependent glucose utilization and UCP1-independent active lipid metabolism in the brown adipose tissue of mice.