What question did this study set out to answer?

To compare uncoupling protein expression and lipid mobilization in response to cold exposure between leptin-resistant obese (db/db) mice and lean littermates.

October 1, 2000AJP Regulatory Integrative and Comparative Physiology

Impaired response of UCP family to cold exposure in diabetic (db/db) mice

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Authors

TMTakayuki MasakiKyushu University HYHironobu YoshimatsuKyushu University SCSeiichi ChibaOita University

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Implication

Controlled animal study reveals blunted uncoupling protein activation and lipolysis during cold exposure in diabetic obese mice, suggesting defective fat breakdown impairs thermoregulation.

Key Points

To compare uncoupling protein expression and lipid mobilization in response to cold exposure between leptin-resistant obese (db/db) mice and lean littermates.
Subjected leptin-resistant obese (db/db) mice and lean (C57Ksj) controls to cold exposure (4 °C) for 12 and 24 hours, followed by rewarming (21 °C) for 12 hours.
Measured tissue-specific mRNA expression of UCP1, UCP2, UCP3, and white adipose tissue lipoprotein lipase, as well as circulating serum free fatty acid concentrations.
Basal brown adipose tissue UCP1 and UCP3 mRNA levels were lower in db/db mice compared to lean littermates, whereas white adipose tissue UCP2 expression was elevated.
Cold exposure upregulated UCP family mRNAs at 12 and 24 hours in lean mice, but this inductive effect was blunted in db/db obese mice.
Cold exposure suppressed white adipose tissue lipoprotein lipase mRNA and elevated serum free fatty acids in lean mice, whereas db/db mice showed no significant changes in either parameter.

Cite This Study

Masaki et al. (2000) studied this question.

synapsesocial.com/papers/6a9726340f79e4f014b3268d https://doi.org/10.1152/ajpregu.2000.279.4.r1305

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Implication

Controlled animal study reveals blunted uncoupling protein activation and lipolysis during cold exposure in diabetic obese mice, suggesting defective fat breakdown impairs thermoregulation.

Impaired response of UCP family to cold exposure in diabetic (db/db) mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Impaired response of UCP family to cold exposure in diabetic (db/db) mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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