Key result
Cold exposure induces a smaller BAT uncoupling protein mRNA increase in obese versus lean mice.
Why the study?
Does cold exposure increase mRNA for uncoupling protein in brown adipose tissue of obese (ob/ob) mice compared to lean mice?
Does cold exposure increase mRNA for uncoupling protein in brown adipose tissue of obese (ob/ob) mice compared to lean mice?
Obese (ob/ob) mice exhibit an attenuated cold-induced increase in uncoupling protein mRNA in brown adipose tissue, likely secondary to chronic reduction in sympathetic nervous system activity.
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Attenuated BAT UCP induction in obese mice signals thermogenic impairment; leaves open translation to human obesity or BAT-targeted interventions.
Reichling et al. (1988) studied Obesity. Cold exposure (14 degrees C) vs. 28 degrees C was evaluated on Level of mRNA for uncoupling protein in brown adipose tissue. Cold exposure induced a smaller absolute increase in uncoupling protein mRNA in brown adipose tissue of obese mice compared to lean mice, regardless of age.
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