Key result
Intraplaque hemorrhage and thin fibrous cap show no link to microembolic signals in mild-to-moderate carotid stenosis.
Why the study?
In patients with mild to moderate symptomatic carotid artery stenosis, the relationship between intraplaque hemorrhage, fibrous cap status, and microembolic signals is unclear.
Does the presence of intraplaque hemorrhage or thin/ruptured fibrous cap on MRI associate with microembolic signals on transcranial Doppler in patients with symptomatic mild to moderate carotid artery stenosis?
Population
113 patients with recent TIA or minor stroke and ipsilateral mild to moderate carotid artery plaque
Comparison
Presence versus absence of intraplaque hemorrhage and thin/ruptured versus thick fibrous cap
Design
Multicenter diagnostic cohort study with blinded transcranial Doppler analysis
Authors
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MRI plaque features should not yet guide embolic risk assessment; leaves open their independent value for stroke prediction.
Cohort (n=113)
Blinded outcome assessment
Yes
Does the presence of intraplaque hemorrhage or thin/ruptured fibrous cap on MRI associate with microembolic signals on transcranial Doppler in patients with symptomatic mild to moderate carotid artery stenosis?
p-value: p=0.46
In patients with symptomatic mild to moderate carotid artery stenosis, MRI-detected intraplaque hemorrhage and fibrous cap status are not associated with transcranial Doppler-detected microembolic signals, suggesting they provide different information on plaque vulnerability.
Truijman et al. (2014) conducted a cohort in Mild to moderate symptomatic carotid artery stenosis (n=113). Intraplaque hemorrhage (IPH) and thin/ruptured fibrous cap (FC) vs. Absence of IPH and thick fibrous cap was evaluated on Prevalence of microembolic signals (MES) (p=0.46). In patients with symptomatic mild to moderate carotid artery stenosis, neither intraplaque hemorrhage (P=0.46) nor thin/ruptured fibrous cap (P=0.48) were associated with microembolic signals.
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