Key result
Normotensive offspring of hypertensive patients have lower forearm venous volume unaffected by ouabain.
Why the study?
Does venous volume and its response to ouabain differ between normotensive offspring of hypertensive patients and controls?
Case-Control (n=40)
Does venous volume and its response to ouabain differ between normotensive offspring of hypertensive patients and controls?
Decreased venous distensibility in normotensive offspring of hypertensive patients may represent an early manifestation of essential hypertension.
May signal early venous changes in hypertension predisposition; hypothesis-generating, needs prospective validation.
Twenty normotensive healthy male offspring of hypertensive patients were compared to 20 adequate controls regarding venous volume, the effect of ouabain on venous volume and signs of left ventricular hypertrophy. Among offspring there were slightly increased amplitudes in the orthogonal ECG as compared to controls but the differences were not statistically significant. Using a plethysmographic technique we found a significantly lower venous volume of the forearm in the offspring than in controls. There was, however, no effect of ouabain on the venous volume. The decreased venous distensibility among normotensive offspring might be an early manifestation of essential hypertension.
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Sallerfors et al. (1984) conducted a case-control in Family history of hypertension (n=40). Family history of hypertension (offspring of hypertensive patients) vs. Adequate controls was evaluated on Venous volume of the forearm. Normotensive male offspring of hypertensive patients had significantly lower forearm venous volume compared to controls, with no effect of ouabain on venous volume.
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