Key result
Oral ju-ling-tang lowers blood pressure and reduces glomerular sclerosis in renal hypertensive rats.
Why the study?
The anti-hypertension effect of the traditional Chinese medicine ju-ling-tang (JLT) on renal hypertension induced by unilateral renal artery ligation was investigated.
Does ju-ling-tang reduce blood pressure and glomerular sclerosis in a rat model of renal hypertension?
Population
Renal hypertensive rats induced by unilateral renal artery ligation
Comparison
Ju-ling-tang 240 mg/kg vs alpha-methyldopa 50 mg/kg vs control
Design
Preclinical animal study
Follow-up
240 minutes for blood pressure monitoring
Authors
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Should not change clinical practice; leaves open further preclinical testing of ju-ling-tang in hypertension.
Does ju-ling-tang reduce blood pressure and glomerular sclerosis in a rat model of renal hypertension?
p-value: p=<0.05
The traditional Chinese medicine ju-ling-tang demonstrates acute blood pressure-lowering effects and reduces glomerular sclerosis in a rat model of renal hypertension.
Shih et al. (2005) studied Renal hypertension. Ju-ling-tang (JLT) vs. Alpha-methyldopa (50 mg/kg orally) and control was evaluated on Decrease in blood pressure (p=<0.05). Oral administration of 240 mg/kg ju-ling-tang significantly decreased blood pressure in renal hypertensive rats (p < 0.05) and reduced glomerular sclerosis compared with control.
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