Key result
Low-dose aspirin reduces thrombin generation only with cholesterol ≤5.2 mmol/L, requiring simvastatin for higher levels.
Why the study?
The effects of low-dose aspirin and additional simvastatin treatment on thrombin generation in coronary heart disease patients with borderline-high cholesterol levels were unclear.
Does low-dose aspirin and simvastatin reduce thrombin generation in patients with coronary heart disease and varying cholesterol levels?
Does low-dose aspirin and simvastatin reduce thrombin generation in patients with coronary heart disease and varying cholesterol levels?
Low-dose aspirin reduces thrombin generation only in patients with desirable cholesterol levels, whereas the addition of simvastatin is required to achieve this effect in those with borderline-high cholesterol.
No takes yet. Share an insight, caveat, or question.
Cholesterol may modulate aspirin's thrombin effect in CHD; hypothesis-generating and should not yet change practice.
A 2001 study studied Coronary heart disease. Low-dose aspirin and simvastatin was evaluated on Thrombin generation ex vivo. Low-dose aspirin (75 mg daily) decreased thrombin generation only in patients with total cholesterol ≤5.2 mmol/L, while the addition of simvastatin reduced it in those with higher cholesterol.
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