Key result
Parecoxib matches ketorolac for post-surgical pain reduction while sparing opioids and causing fewer gastroduodenal ulcers.
Why the study?
Does parecoxib reduce pain following surgery compared to ketorolac or placebo?
Population
Patients following oral, orthopedic, gynecologic and cardiac surgeries
Comparison
Parecoxib (parenteral cyclooxygenase-2 inhibitor) vs Ketorolac or placebo
Design
Review
Authors
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No reduction in opioid GI side effects with parecoxib; leaves open whether COX-2 inhibitors mitigate postoperative opioid morbidity.
Does parecoxib reduce pain following surgery compared to ketorolac or placebo?
Parecoxib is an effective parenteral COX-2 inhibitor for post-surgical pain management with a favorable gastrointestinal and hematologic safety profile compared to traditional NSAIDs like ketorolac.
Dalpiaz et al. (2004) conducted a review in Postoperative pain. Parecoxib vs. Ketorolac and placebo was evaluated on Pain reduction. Parecoxib provided dose-related pain reduction similar to ketorolac following surgery, with an opioid-sparing effect and fewer gastroduodenal ulcers than ketorolac.
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