The strong dependence of the NOE on the molecular mobility rendered the weak bond of a homotypical carbohydrate–carbohydrate recognition detectable in a simplified model system. The membrane-bound LeX trisaccharide 1, which functions as a receptor, transiently binds the dissolved LeX trisaccharide 2, thus slowing down its rotational diffusion. This kind of molecular recognition plays an important part in cell adhesion.
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Geyer et al. (1999) studied this question.