Key result
Cardiac micro-RNAs surge up to ~4,000-fold after pediatric cardiac surgery, correlating with troponin and delayed discharge.
Why the study?
Cardiac-enriched micro-RNAs as biomarkers for myocardial injury and predictors of postoperative course after pediatric cardiac surgery have not been established.
Do plasma levels of micro-RNA-208a, -208b, and -499 correlate with myocardial injury and postoperative course in pediatric patients undergoing open heart surgery for congenital heart defects?
Observational (n=30)
Do plasma levels of micro-RNA-208a, -208b, and -499 correlate with myocardial injury and postoperative course in pediatric patients undergoing open heart surgery for congenital heart defects?
Cardiac-enriched micro-RNAs (208a, 208b, 499) significantly increase after pediatric congenital heart surgery and correlate with established myocardial injury markers and clinical recovery.
Answers are grounded in this paper and cite their sources.
Cardiac miRNAs may correlate with injury and course after pediatric cardiac surgery; leaves open biomarker utility pending validation.
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Bolkier et al. (2016) conducted an observational in Congenital heart defects (n=30). Plasma levels of micro-RNA-208a, -208b, and -499 vs. Preoperative levels was evaluated on Plasma levels of micro-RNAs at 12 hours post surgery (300- to 4,000-fold increase). Plasma levels of micro-RNA-208a, -208b, and -499 increased by 300- to 4,000-fold at 12 hours after pediatric cardiac surgery and correlated with troponin levels and delayed hospital discharge.
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