Key result
Plasma concentrations of miR-208b and miR-499 were significantly elevated in patients with acute myocardial infarction compared to healthy controls, showing similar diagnostic properties to cTnT.
Why the study?
Do plasma levels of miR-208b and miR-499 serve as potential biomarkers for acute myocardial infarction in a Greek population?
Case-Control
Do plasma levels of miR-208b and miR-499 serve as potential biomarkers for acute myocardial infarction in a Greek population?
Plasma levels of miR-208b and miR-499 are significantly elevated in AMI patients and show similar diagnostic properties to cardiac troponin T, supporting their potential use as AMI biomarkers.
Supports miR-208b/miR-499 evaluation as AMI biomarkers; leaves open prospective validation before clinical use.
BACKGROUND/AIM: Certain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) in a Greek pathological population. MATERIALS AND METHODS: Plasma samples from AMI patients and healthy subjects (controls) were analyzed using TaqMan® MicroRNA assays. RESULTS: The concentration of both miRs was significantly elevated in AMI patients compared to healthy controls. Moreover, receiver-operating characteristic (ROC) curve analysis showed that miR-208b and miR-499 displayed similar properties with the established AMI biomarker cardiac troponin T (cTnT). CONCLUSION: We showed, for the first time, that these miRs could be used as AMI biomarkers in our population as well. Our data are in agreement with those of studies based on different population groups and further strengthen the observation that plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers.
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Αγιαννιτόπουλος et al. (2018) conducted a case-control in Acute Myocardial Infarction. miR-208b and miR-499 biomarker assessment vs. Healthy controls was evaluated on Concentration of miR-208b and miR-499 and ROC curve properties. Plasma concentrations of miR-208b and miR-499 were significantly elevated in patients with acute myocardial infarction compared to healthy controls, showing similar diagnostic properties to cTnT.
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