Key result
Circulating microRNA-499 demonstrated high diagnostic accuracy for acute myocardial infarction, with a pooled sensitivity of 0.84, specificity of 0.97, and a diagnostic odds ratio of 188.
Why the study?
Circulating microRNA-499 could be a powerful biomarker for acute myocardial infarction, but its diagnostic performance required formal evaluation.
Does circulating microRNA-499 accurately diagnose acute myocardial infarction?
Meta-Analysis (n=3,816)
Does circulating microRNA-499 accurately diagnose acute myocardial infarction?
Odds Ratio: 188 (95% CI 19–1815)
Circulating microRNA-499 demonstrates high diagnostic accuracy for acute myocardial infarction, suggesting it is a reliable biomarker, though its performance is comparable to standard cardiac troponin T.
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Supports miR-499 evaluation as AMI biomarker; leaves open incremental value over troponin in practice.
Zhao et al. (2019) conducted a meta-analysis in Acute myocardial infarction (n=3,816). Circulating microRNA-499 vs. Cardiac troponin T (cTnT) was evaluated on Diagnostic accuracy for acute myocardial infarction (DOR 188, 95% CI 19-1815). Circulating microRNA-499 demonstrated high diagnostic accuracy for acute myocardial infarction, with a pooled sensitivity of 0.84, specificity of 0.97, and a diagnostic odds ratio of 188.
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