Why the study?
Do circulating miRNAs have high sensitivity and specificity as diagnostic biomarkers for myocardial infarction?
Population
19 studies evaluating patients for myocardial infarction
Design
Meta-analysis
Authors
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Supports miR-499 evaluation for MI diagnosis; extends meta-analytic data but requires prospective validation before clinical adoption.
Do circulating miRNAs have high sensitivity and specificity as diagnostic biomarkers for myocardial infarction?
Circulating miRNAs, particularly miR-499 and miR-133a, demonstrate high sensitivity and specificity, suggesting potential utility as diagnostic biomarkers for myocardial infarction.
Cheng et al. (2014) studied this question.
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