Key result
MicroRNA-499 demonstrates high diagnostic accuracy for AMI with an AUC of 0.98.
Why the study?
To assess the diagnostic efficacy of MicroRNA-499 in cases of acute myocardial infarction.
Does circulating microRNA-499 accurately diagnose acute myocardial infarction?
Meta-Analysis (n=3,887)
Does circulating microRNA-499 accurately diagnose acute myocardial infarction?
Effect estimate: AUC 0.98 (95% CI 0.97-0.99)
Circulating microRNA-499 exhibits high sensitivity and specificity for diagnosing acute myocardial infarction, indicating its potential as a valuable diagnostic biomarker.
Supports microRNA-499 evaluation in AMI; leaves open routine use pending prospective validation.
Background: The objective of this study was to assess the diagnostic efficacy of MicroRNA-499 in cases of acute myocardial infarction. Methods: On May 6, 2023, four electronic databases PubMed, Embase, Web of Science, and Cochrane Library were searched with no time restriction. Quality assessment was conducted using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Random-effects metaanalysis was employed to combine sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). The evaluation of publication bias was conducted through the utilization of Deeks' asymmetry test on the funnel plot. Results: The studies that were included in the analysis, encompassing sample sizes ranging from 63 to 1155, exhibited a pooled sensitivity of 0.88 and a specificity of 0.97. The pooled PLR was determined to be 29.78, while the NLRwas found to be 0.13. Furthermore, the pooled DOR was calculated to be 236.10. The area under the curve (AUC) was reported as 0.98. Conclusions: MicroRNA-499 exhibits high sensitivity and specificity for diagnosing Acute Myocardial Infarction, indicating its potential as a valuable diagnostic biomarker.
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Du et al. (2024) conducted a meta-analysis in Acute Myocardial Infarction (n=3,887). MicroRNA-499 vs. Healthy individuals or patients with non-AMI cardiovascular diseases was evaluated on Area under the curve (AUC) for diagnosing AMI (AUC 0.98, 95% CI 0.97-0.99). MicroRNA-499 demonstrated high diagnostic accuracy for acute myocardial infarction, with a pooled sensitivity of 0.88, specificity of 0.97, and an area under the curve of 0.98.
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