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This review aims to evaluate the diagnostic accuracy of circulating microRNA-208 for early detection of acute myocardial infarction.

July 15, 2026MedicinaOpen Access

Bridging the Troponin Blind Window via the miAMI Standard: A Systematic Review and Meta-Analysis of the Circulating MicroRNA-208 Family

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Systematic review demonstrates circulating miR-208's potential for early AMI detection, indicating future research needs.

This review aims to evaluate the diagnostic accuracy of circulating microRNA-208 for early detection of acute myocardial infarction.
Systematic search conducted in PubMed and Embase up to June 24th, 2026.
Analysis included 41 studies with 6306 participants; 14 were eligible for meta-analysis.
Pooled sensitivity and specificity were estimated using bivariate random effects modeling.
Pooled sensitivity for AMI detection was 0.89 (95% CI: 0.81–0.94) and specificity was 0.90 (95% CI: 0.83–0.94).
Subgroup analysis indicated higher sensitivity in isolated STEMI (0.95) or NSTEMI (0.93) compared to mixed populations (0.65; p < 0.0001).
Specificity decreased from 0.90 with healthy controls to 0.80 with non-AMI controls (p = 0.002), indicating spectrum bias.

Crabbe et al. (2026) studied this question.

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