Key result
Modified CPB with higher perfusion flow during pregnancy is linked to improved foetal survival.
Why the study?
Open heart surgeries during pregnancy carry extremely high fetal mortality, and modifications to cardiopulmonary bypass protocols may improve fetal survival while maternal survival depends more on cardiac disease.
Do modified cardiopulmonary bypass protocols improve foetal survival in pregnant women undergoing open heart surgery?
Case Report (n=3)
Do modified cardiopulmonary bypass protocols improve foetal survival in pregnant women undergoing open heart surgery?
Modified cardiopulmonary bypass protocols, including higher perfusion flow and tocolytic agents, may improve foetal survival during open heart surgery in pregnancy.
Extreme caution remains warranted for open heart surgery in pregnancy; hypothesis-generating for modified bypass protocols to enhance fetal survival.
Since foetal mortality is extremely high, open heart surgeries during pregnancy should be tried with extreme caution. Some deviation from routine cardiopulmonary bypass protocols like higher perfusion flow, pressure and arterial oxygen tension, use of Tocolytic agents might result in improved foetal survival though maternal survival seems to depend on cardiac disease per se than on cardiopulmonary bypass. Foetal bradycardia is the earliest indication of foetal distress and must be aggressively managed.
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A 2007 study conducted a case report in Pregnancy requiring open heart surgery (n=3). Cardiopulmonary bypass was evaluated. Cardiopulmonary bypass during pregnancy requires protocol deviations like higher perfusion flow to improve foetal survival, while maternal survival depends on the underlying cardiac disease.
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