A Colonic Mass Unmasked as an Ameboma: Mimicry in the Gut

Ameboma is a rare complication of invasive intestinal amebiasis caused by Entamoeba histolytica , which often mimics colonic malignancy due to its mass-like appearance. The disease remains endemic in tropical and subtropical regions, with an estimated 50 million cases of invasive amebiasis reported worldwide each year. Ameboma is characterized by a granulation tissue mass with central inflammation and peripheral fibrosis, which may result in intestinal obstruction or lead to a misdiagnosis of cancer. Here, we present the case of a 60-year-old female with obstructive gastrointestinal symptoms, managed surgically with subsequent histopathological confirmation of ameboma. The presence of characteristic E. histolytica trophozoites with erythrophagocytosis confirmed the diagnosis. Early recognition of this uncommon entity is crucial to avoid misdiagnosis, unnecessary surgical resection, and delays in appropriate medical management.