Amide-zing: The reaction between 2 equivalents of Ph2P(CH2)2NH2 and cis-[Ru(CH3CN)2(η3-C3H5)(cod)]BF4 (cod=1,5-cyclooctadiene) forms a highly active catalyst precursor for the selective hydrogenation of amides. The reaction proceeds with excellent atom economy, yield, and turnover numbers (TONs) under moderate reaction conditions. The technology offers a greener, practical approach to the use of metal hydride reagents commonly employed in both academia and industry.
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John et al. (2011) studied this question.
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