Key result
Scheduled NSAIDs are linked to ~40% less opioid use 48 hours post-procedure versus routine care.
Why the study?
Increasing utilization of non-opioid analgesics to achieve adequate pain relief is essential for reducing adverse outcomes associated with opioid use.
Observational (n=212)
No
Answers are grounded in this paper and cite their sources.
May support scheduled NSAIDs for postoperative opioid reduction; hypothesis-generating and requires randomized confirmation before practice change.
Improving postoperative outcomes by achieving adequate pain relief and increasing utilization of non-opioid analgesics is essential in reducing adverse outcomes associated with opioid use. The purpose of this study was to evaluate the difference in opioid requirements for patients utilizing scheduled non-steroidal anti-inflammatory drugs after laparoscopic appendectomy or cholecystectomy versus routine care in postoperative analgesia.
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Austin et al. (2024) conducted an observational in Postoperative pain after laparoscopic appendectomy or cholecystectomy (n=212). Scheduled non-steroidal anti-inflammatory drugs vs. Routine care (as needed opioids, acetaminophen, or NSAIDs) was evaluated on Total morphine milligram equivalents (MME) of opioids utilized up to 48 hours post-procedure (MD 17.9, 95% CI 6.9-28.9, p=0.002). Scheduled non-steroidal anti-inflammatory drugs significantly reduced total opioid utilization up to 48 hours post-procedure compared to routine care (mean difference 17.9 MME, p=0.002).
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