What is the clinical evidence from this study?

Study design: Case Report. Population: Traumatic brain injury and propofol infusion syndrome (n=1). Intervention: Propofol infusion and frequent biochemical monitoring. Primary outcome: Death due to propofol infusion syndrome.

What does this research mean for the field?

Frequent monitoring of biochemical parameters and immediate discontinuation of propofol cannot always prevent fatal propofol infusion syndrome. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

March 1, 2009Pediatric Critical Care Medicine

Monitoring biochemical parameters as an early sign of propofol infusion syndrome: False feeling of security

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Key result

Frequent biochemical monitoring during propofol sedation fails to prevent fatal propofol infusion syndrome.

Why the study?

Frequent monitoring of biochemical parameters is recommended to detect propofol infusion syndrome early, but its effectiveness in preventing fatal outcomes is uncertain.

Comparison

Sedation with propofol and frequent biochemical monitoring vs no comparison

Design

Case report

Authors

EVEsther S. VeldhoenUtrecht University BHBarend J. Hartman JGJosephus P. J. van GestelUniversity Medical Center Utrecht

Discussion

Member takes

Implication

Frequent biochemical monitoring may not prevent fatal propofol infusion syndrome; leaves open safer sedation strategies in pediatric TBI.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 17-year-old patient with traumatic brain injury who developed fatal propofol infusion syndrome despite frequent biochemical monitoring.

Exposure

Sedation with propofol, with frequent monitoring of blood gases, serum lactate, and creatine kinase to screen for propofol infusion syndrome (PRIS)

Outcome

Development of fatal propofol infusion syndrome (PRIS)safety

Frequent monitoring of biochemical parameters may not be sufficient to prevent fatal propofol infusion syndrome.

Cite This Study

Veldhoen et al. (2009) conducted a case report in Traumatic brain injury and propofol infusion syndrome (n=1). Propofol infusion and frequent biochemical monitoring was evaluated on Death due to propofol infusion syndrome. Frequent monitoring of biochemical parameters during propofol sedation failed to prevent fatal propofol infusion syndrome in a 17-year-old patient with traumatic brain injury.

synapsesocial.com/papers/6aa93ca2f8a0f24777263efe https://doi.org/10.1097/pcc.0b013e3181956bda

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Monitoring biochemical parameters as an early sign of propofol infusion syndrome: False feeling of security

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Monitoring biochemical parameters as an early sign of propofol infusion syndrome: False feeling of security

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider