Key result
TCA-induced hepatocellular carcinoma in rats elevates serum AFP, TGAGs, and ACAS while reducing TLPL activity.
Why the study?
New or highly pertinent rapid and sensitive markers for early diagnosis of hepatocellular malignant changes are needed to improve detection of hepatocellular carcinoma.
Do TGAGs, TLPL, and ACAS serve as early diagnostic markers for hepatocellular carcinoma in a TCA-induced rat model?
Do TGAGs, TLPL, and ACAS serve as early diagnostic markers for hepatocellular carcinoma in a TCA-induced rat model?
Absolute Event Rate: 510% vs 7%
p-value: p=<0.001
Serum TGAGs, TLPL, and ACAS activities may serve as a novel panel of early diagnostic markers for hepatocellular carcinoma to improve the sensitivity and specificity of AFP.
Should not change clinical practice; leaves open translational relevance of these markers to human hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) accounts for 80% to 90% of primary liver cancer and it is a major health problem worldwide, ranking the fifth most common cancer in the world. In the present study we aimed to explore new or highly pertinent rapid and sensitive markers for early diagnosis of hepatocellular malignant changes. Two groups of rats were used in this study, one served as control, the second as trichloroacetic acid (TCA) challenged group (0.5 g/kg/d for 5 days, sacrificed after 4 weeks). The results showed that TCA group had a significant increase in blood alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase ( ALP), and acetyl CoA synthase (ACAS) activities, total bilirubin, triglycerides, total glycosaminoglycans (TGAGs), parallel with alpha-fetoprotein (AFP). On the other hand, it induced a significant reduction in serum total lipoprotein lipase (TLPL) activity. The histopathological investigations of hepatic tissue confirmed these neoplastic changes induced by TCA. The three parameters (TGAGs level, TLPL and ACAS activities) can be added as new markers for early diagnosis of hepatocellular carcinoma and elevation of the sensitivity and specificity of AFP.
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Abdel‐Hamid et al. (2012) studied Hepatocellular Carcinoma (n=16). Trichloroacetic acid (TCA) vs. Untreated normal healthy group was evaluated on Serum alpha-fetoprotein (AFP) level (p=<0.001). Trichloroacetic acid-induced hepatocellular carcinoma in rats significantly increased serum alpha-fetoprotein, total glycosaminoglycans, and acetyl CoA synthase, while reducing total lipoprotein lipase activity.
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